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Article

Changes in LCI in F508del/F508del patients treated with lumacaftor/ivacaftor: Results from the prospect study.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Nov 2020

Shaw Michelle, Khan Umer, Clancy John P, Donaldson Scott H, Sagel Scott D, Rowe Steven M, Ratjen Felix

Abstract excerpt

The PROSPECT study, a post-approval observational study in the U.S., showed no significant changes in lung function as measured by spirometry with clinical initiation of lumacaftor/ivacaftor. A sub-study within the PROSPECT study assessed the lung clearance index (LCI), as measured by multiple breath washout (MBW), a measure of lung function demonstrated to be sensitive among people with normal spirometry....

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Identifiers

PMID: 32513528
DOI: 10.1016/j.jcf.2020.05.010
PMCID: PMC9125683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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