Back to search

Article

Identification of differentially expressed proteins in papillary thyroid carcinomas with V600E mutation of BRAF.

2007-07-01

Abstract excerpt

BRAF, a serine/threonine kinase of the RAF family, is a downstream transducer of the RAS-regulated MAPK pathway. V600E mutation of BRAF protein is the most common genetic alteration occurring in papillary thyroid carcinomas and is prognostic of poor clinicopathological outcomes. Protein expression in the subclass of PTC bearing the BRAFV 600E mutation was investigated by using 2-DE and MS/MS techniques and compare...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
10c88860-b171-545c-9391-0a0e962b3181
DOI
10.1002/prca.200600776
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of differentially expressed proteins in papillary thyroid carcinomas with V600E mutation of BRAF.DOI 10.1002/prca.200600776
Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).Semantic proximity
BRAF-Oncogene-Induced Senescence and the Role of Thyroid-Stimulating Hormone Signaling in the Progression of Papillary Thyroid Carcinoma.Semantic proximity
Metabolomic analysis of human papillary thyroid carcinoma using UPLC-Q- TOFMSSemantic proximity
BRAF V600E in papillary thyroid carcinoma is associated with increased programmed death ligand 1 expression and suppressive immune cell infiltration.Semantic proximity
Increased CYP24A1 expression is associated with BRAF(V600E) mutation and advanced stages in papillary thyroid carcinoma.Semantic proximity
Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib.Semantic proximity
ERK phosphorylation is not increased in papillary thyroid carcinomas with BRAF(V600E) mutation compared to that of corresponding normal thyroid tissues.Semantic proximity
Proteomic analysis of papillary thyroid carcinoma in the context of Hashimoto’s thyroiditisSemantic proximity
BRAF(V600E) mutation influences hypoxia-inducible factor-1alpha expression levels in papillary thyroid cancer.Semantic proximity
Translationally controlled tumor protein: A protein identified in several nontumoral cells including erythrocytesSemantic proximity
Combined BRAF and PIM1 inhibitory therapy for papillary thyroid carcinoma based on BRAFV600E regulation of PIM1: Synergistic effect and metabolic mechanisms.Semantic proximity
Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas.Semantic proximity
Select a neighboring publication to make it the new centre.