Article

Exploring Clinical Class 1 Integrons as Valuable Targets for the Re-sensitization of Multidrug Resistant Pathogenic Bacteria Using CRISPR-Cas

2025-03-28

Abstract excerpt

The increasing prevalence of bacteria resistant to many or all types of antibiotics poses a major health crisis. Novel classes of antibiotics are only slowly being developed and alternative strategies are needed to tackle the issue. Mobile genetic elements and class 1 integrons are important facilitators for antibiotic resistance genes, with the latter being highly conserved in human pathogens. The growing prevale...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10b78732-4bb3-586c-895b-d2b03e73acbb
DOI: 10.1101/2025.03.28.645910

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring Clinical Class 1 Integrons as Valuable Targets for the Re-sensitization of Multidrug Resistant Pathogenic Bacteria Using CRISPR-CasDOI 10.1101/2025.03.28.645910Read

Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.Semantic proximity Read

Harnessing CRISPR interference to re-sensitize laboratory strains and clinical isolates to last resort antibioticsSemantic proximity Read

CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogensSemantic proximity Read

Effectiveness of CRISPR-Cas in Sensitizing Bacterial Populations with Plasmid-Encoded Antimicrobial ResistanceSemantic proximity Read

Phage-plasmids spread antibiotic resistance genes through infection and lysogenic conversionSemantic proximity Read

Bacterial resistance to CRISPR-Cas antimicrobials.Semantic proximity Read

An attenuated CRISPR-Cas system in Enterococcus faecalis permits DNA acquisitionSemantic proximity Read

Targeted-Antibacterial-Plasmids (TAPs) combining conjugation and CRISPR/Cas systems achieve strain-specific antibacterial activitySemantic proximity Read

CRISPR-Cas. A Revolution in the Treatment and Study of ESKAPE Infections: Pre-Clinical StudiesSemantic proximity Read

Multidrug-Resistant Enterococci Lack CRISPR- casSemantic proximity Read

Enterococcus faecalis strains with compromised CRISPR-Cas defense emerge under antibiotic selection for a CRISPR-targeted plasmidSemantic proximity Read

Integrons in the Intestinal Microbiota as Reservoirs for Transmission of Antibiotic Resistance GenesSemantic proximity Read