Article

Key residue for aggregation of amyloid-β peptides

2022-02-24

Abstract excerpt

<title>Abstract</title> <p>Amyloid-b peptides (Abs) are associated with Alzheimer’s disease and have two isoforms: Ab40 and Ab42. Although the difference between Ab40 and Ab42 is only two additional C-terminal residues, Ab42 aggregates much faster and is more toxic than Ab40. It is unknown what role the C-terminal two residues play in accelerating aggregation. Clarifying the differences between the oligomerizatio...

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Literature Corpus work: 10b240c6-a1ec-5ed5-8e9f-2ded58f5784e
DOI: 10.21203/rs.3.rs-1337043/v1

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