Article

Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizures

2022-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Spike-and-wave discharges (SWDs), generated by the cortico-thalamo-cortical (CTC) network, are pathological, large amplitude oscillations and the hallmark of absence seizures (ASs). SWDs begin in a cortical initiation network in both humans and animal models, including the Genetic Absence Epilepsy Rats from Strasbourg (GAERS), where it is located in the primary somatosensory cortex (S1). The beh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 105698c6-bc4a-57ce-a3dd-153efe6781f2
DOI: 10.1101/2022.12.02.518853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizuresDOI 10.1101/2022.12.02.518853Read

Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic modelSemantic proximity Read

Interpretable Machine Learning Identifies an Emergent Absence Seizure MechanismSemantic proximity Read

Decreased overall neuronal activity in a rodent model of impaired consciousness during absence seizuresSemantic proximity Read

Unified Analysis of Global and Focal Aspects of Absence Epilepsy via Neural Field Theory of the Corticothalamic SystemSemantic proximity Read

Single-neuron bursts encode pathological oscillations in Parkinson’s disease and essential tremorSemantic proximity Read

Distinct signatures of loss of consciousness during Focal Impaired Awareness versus Focal to Bilateral Tonic Clonic seizuresSemantic proximity Read

The role of thalamic nuclei in genetic generalized epilepsiesSemantic proximity Read

Human Mediodorsal Thalamus in Seizure PropagationSemantic proximity Read

Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG-Defined Network Classification.Semantic proximity Read

Multi-unit activity and high-gamma patterns dissociate in the seizure onset zone during focal to bilateral tonic-clonic seizuresSemantic proximity Read

Region-specific spreading depolarization drives aberrant post-ictal behaviorSemantic proximity Read

Unstable Slow Oscillations Couple with Epileptogenic Fast-Rhythm Bistability in Sleep-Related Epilepsy: An SEEG StudySemantic proximity Read