Article

NNMT-LOX-FAK axis orchestrates the intergrowth of fibroblasts and tumor cells in oral squamous cell carcinoma: evidence from the patient-derived assembled organoids

2022-09-13

Abstract excerpt

<title>Abstract</title> Nicotinamide N-methyltransferase (NNMT) has been reported to link with the methylation reprogramming in cancer cells. However, the role of NNMT in tumor microenvironment (TME) remained elusive. Here, we found that the expression of NNMT was elevated in the stroma of oral squamous cell carcinoma (OSCC). Using a fibroblast-attached organoids (FAOs) model, we found that the stromal NNMT ex...

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Literature Corpus work: 104ed30f-d28a-5216-8bc4-01bdc5c6aed7
DOI: 10.21203/rs.3.rs-2009951/v1

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