Article

Cryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues

2019-12-02

Abstract excerpt

OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. Here we report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS decreases ion-beam induced fragmentation, allowing large molecules such as triglycerides to be more reliably identified. It...

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Literature Corpus work: 0fc0609c-eb4c-57f1-b82e-ac1188a0cb65
DOI: 10.1101/862391

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