Article
Maternal senescence broadly reprograms gene expression in offspring
2026-05-01
Abstract excerpt
Offspring of older parents have reduced fitness in many species, but the mechanisms mediating this cross-generational dimension of ageing remain poorly understood. Senescence is associated with genome-wide epigenetic changes that alter transcription, raising the possibility that older parents transmit dysregulated gene expression patterns. Here we show that maternal senescence induces deleterious, transcriptome-wi...
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Identifiers and source
- Literature Corpus work
- 0faa60cc-2852-5b7e-9f34-2bb716f7ddcd
- DOI
- 10.64898/2026.04.28.720237