Article

Somatic cell gene therapy for diabetes mellitus : engineering a surrogate B-cell

1996-01-01

Abstract excerpt

Improved methods of insulin delivery are required for the treatment of insulin-dependent diabetes mellitus (IDDM) to achieve a more physiological profile of glucose homeostasis. Somatic cell gene therapy offers the prospect that insulin could be delivered by an autologous cell implant, engineered to secrete insulin in response to glucose. This study explores the feasibility of manipulating somatic cells to behave...

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Literature Corpus work: 0f978956-0cc9-548a-8526-bded6e8cb5da
DOI: 10.48780/publications.aston.ac.uk.00010940

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