Article

Preconception Genetic Carrier Screening for Miscarriage Risk Assessment: A Bioinformatic Approach to Identifying Candidate Lethal Genes and Variants

2023-06-03

Abstract excerpt

<h4>Purpose</h4> Miscarriage, due to genetically heterogeneous etiology, is a common outcome of pregnancy. Preconception genetic carrier screening (PGCS) identifies at-risk partners for newborn genetic disorders; however, PGCS panels currently lack miscarriage-related genes. Here we assessed the theoretical impact of known and candidate genes on prenatal lethality and the PGCS among diverse populations. <h4>Metho...

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Literature Corpus work: 0f7d3d8c-eda4-5abc-992a-9dee2b057ce8
DOI: 10.1101/2023.05.25.23290518

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