Article
The genetic architecture of sporadic and multiple consecutive miscarriage.
Nature communications - 25 Nov 2020
Laisk Triin, Soares Ana Luiza G, Ferreira Teresa, Painter Jodie N, Censin Jenny C, Laber Samantha, Bacelis Jonas, Chen Chia-Yen, Lepamets Maarja, Lin Kuang, Liu Siyang, Millwood Iona Y, Ramu Avinash, Southcombe Jennifer, Andersen Marianne S, Yang Ling, Becker Christian M, Børglum Anders D, Gordon Scott D, Bybjerg-Grauholm Jonas, Helgeland Øyvind, Hougaard David M, Jin Xin, Johansson Stefan, Juodakis Julius, Kartsonaki Christiana, Kukushkina Viktorija, Lind Penelope A, Metspalu Andres, Montgomery Grant W, Morris Andrew P, Mors Ole, Mortensen Preben B, Njølstad Pål R, Nordentoft Merete, Nyholt Dale R, Lippincott Margaret, Seminara Stephanie, Salumets Andres, Snieder Harold, Zondervan Krina, Werge Thomas, Chen Zhengming, Conrad Donald F, Jacobsson Bo, Li Liming, Martin Nicholas G, Neale Benjamin M, Nielsen Rasmus, Walters Robin G, Granne Ingrid, Medland Sarah E, Mägi Reedik, Lawlor Deborah A, Lindgren Cecilia M
Abstract excerpt
Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366,...
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