Article

Shikonin triggers apoptosis in lung adenocarcinoma through FHL2-FOXO1 signaling axis

2025-12-08

Abstract excerpt

<title>Abstract</title> <p>Background: FHL2 is an oncogenic scaffold protein overexpressed in lung LUAD, making it a promising therapeutic target. SHK a natural naphthoquinone, exhibits anti-tumor activity, but its molecular mechanism in LUAD, particularly its relationship with FHL2, remains unclear. Aim of the study: The present study aimed to define the effects of SHK on NSCLC and identify the potential molecul...

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Literature Corpus work: 0f5e2909-bf1e-564f-a4e9-3a80f6b828e9
DOI: 10.21203/rs.3.rs-8119297/v1

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