Article

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

2003-12-01

Abstract excerpt

Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL) Ab's. Currently, therapy for pregnant women with APS is focused on preventing thrombosis, but anticoagulation is only partially successful in averting miscarriage. We hypothesized that complement activation is a central mechanism of pregnancy loss in APS and tested this in a model in whic...

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Literature Corpus work: 0f4b5d7a-be7c-5298-b344-ab252bb46f8b
DOI: 10.1172/jci200318817

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