Article

Spatial genome organization in nematodes with programmed DNA elimination

2025-10-24

Abstract excerpt

Programmed DNA elimination (PDE) is a notable exception to genome integrity, characterized by significant DNA loss during development. In many nematodes, PDE is initiated by DNA double-strand breaks (DSBs), which lead to chromosome fragmentation and subsequent DNA loss. However, the mechanism of nematode programmed DNA breakage remains largely unclear. Interestingly, in the human and pig parasitic nematode Ascari...

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Literature Corpus work: 0f14b941-5e68-5918-b0b0-a04d2652fd95
DOI: 10.1101/2025.10.23.684251

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