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Effect of seizures on the severity of myelin vacuolization in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts

2024-04-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a white matter disease characterized by myelin vacuolization and swollen perivascular astrocyte processes. Neuronal activity has been implicated as primary cause of myelin vacuolization and astrocyte swelling. Since acute and excessive increases in neuronal activity occur in MLC during seizures, we investigat...

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Literature Corpus work
0f0549d2-db74-56ad-969a-6af6f390adba
DOI
10.1101/2024.04.23.590685
Open publication

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Effect of seizures on the severity of myelin vacuolization in a mouse model of megalencephalic leukoencephalopathy with subcortical cystsDOI 10.1101/2024.04.23.590685
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