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Article

Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.

Glia - 1 Jan 2017

Sugio Shouta, Tohyama Koujiro, Oku Shinichiro, Fujiyoshi Kanehiro, Yoshimura Takeshi, Hikishima Keigo, Yano Ryutaro, Fukuda Takahiro, Nakamura Masaya, Okano Hideyuki, Watanabe Masahiko, Fukata Masaki, Ikenaka Kazuhiro, Tanaka Kenji F

Abstract excerpt

Astrocytes have recently been shown to provide physiological support for various brain functions, although little is known about their involvement in white matter integrity. Several inherited infantile-onset leukoencephalopathies, such as Alexander disease and megalencephalic leukoencephalopathy with subcortical cysts (MLC), implicate astrocytic involvement in the formation of white matter. Several mouse models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27748972
DOI: 10.1002/glia.23084

Genes

MLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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