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Article

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells

1 Jan 2018

Abstract excerpt

The purpose of this study was to devise a strategy for the derivation of corneal endothelial cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs were generated from an adult human with normal ocular history via expression of OCT4, SOX2, KLF4 and c-MYC. Neural crest cells (NCCs) were differentiated from iPSCs via addition of CHIR99021 and SB4315542. NCCs were driven toward a...

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PMID: 29685994
DOI: 10.1242/bio.032102

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