Article

Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson’s disease across diverse ancestral populations

2025-07-24

Abstract excerpt

Variants in PGLYRP2 , particularly rs892145-T, have been suggested as Parkinson’s disease (PD) risk factors. We analyzed data from 31,334 PD patients and 17,772 controls across diverse ancestries. A significant sex-dependent effect of rs892145-T was observed in African (AFR) ancestry males (OR=0.73, 95%CI: 0.57-0.94, p=0.014). Gene-based analyses identified another variant, rs7251871-A, as significantly associated...

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Literature Corpus work: 0e952c68-2ba8-5f36-a28f-480a7dbe1a2e
DOI: 10.1101/2025.07.23.25331993

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