Article

Rare and Common Germline and Somatic Variants Shape Immune Cytopenia Risk and Enable Risk Stratification

2026-08-31

Abstract excerpt

The genetic risk factors of immune cytopenias are unclear. Immune cytopenias have been reported in various genetic contexts: 1) inherited error of immunity genes, mainly due to rare germline variants, 2) systemic lupus erythematosus, associated with common germline variants, 3) hematological malignancies, and 4) clonal hematopoiesis, the latter two due to somatic variants. However, the respective contribution and...

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Literature Corpus work: 0e299177-1a4d-5ab5-a0ec-0c7d6482fd9a
DOI: 10.64898/2026.08.26.26361484

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