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Article

Somatic mosaicism in inborn errors of immunity: Current knowledge, challenges, and future perspectives.

Seminars in immunology - 1 May 2023

Aluri Jahnavi, Cooper Megan A

Abstract excerpt

Inborn errors of immunity (IEI) are a diverse group of monogenic disorders of the immune system due to germline variants in genes important for the immune response. Over the past decade there has been increasing recognition that acquired somatic variants present in a subset of cells can also lead to immune disorders or 'phenocopies' of IEI. Discovery of somatic mosaicism causing IEI has largely arisen from...

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Identifiers

PMID: 37062181
DOI: 10.1016/j.smim.2023.101761
PMCID: PMC11321052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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