Article

Zinc and Oxo-Vanadium Complexes upon Binding to Phosphatase Enzymes: Structure, Electronics and Implications

2025-03-03

Abstract excerpt

Oxovanadium and zinc complexes are reported as insulin-mimetics. They inhibit several proteins including enzymes which belong to the same class of membrane sensitive phosphatases, similar in terms of general architecture and biochemistry of the active site. Borrowing from this summary, we explore the structural and electronic properties of representative oxovanadium and zinc complexes as computed in isolation and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e131a9a-7826-5ec8-8275-b94acf95de8b
DOI: 10.20944/preprints202503.0112.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Zinc and Oxo-Vanadium Complexes upon Binding to Phosphatase Enzymes: Structure, Electronics and ImplicationsDOI 10.20944/preprints202503.0112.v1Read

Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: A Kinetic ApproachSemantic proximity Read

Design of a single protein that spans the entire 2-V range of physiological redox potentials.Semantic proximity Read

QM/MM analysis suggests that Alkaline Phosphatase (AP) and nucleotide pyrophosphatase/phosphodiesterase slightly tighten the transition state for phosphate diester hydrolysis relative to solution: implication for catalytic promiscuity in the AP superfamily.Semantic proximity Read

Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays.Semantic proximity Read

Decoupling of catalysis and transition state analog binding from mutations throughout a phosphatase revealed by high-throughput enzymology.Semantic proximity Read

Modifying recombinant purple acid phosphatase using computational design.Semantic proximity Read

A structural basis for lithium and substrate binding of an inositide phosphatase.Semantic proximity Read

A Sustained Electronic Signaling Platform for Restoring Vascular Sensitivity and Systemic Homeostasis in Enzyme-Deficient EnvironmentsSemantic proximity Read

Electrically programmable picoscale phototransduction of a newly discovered microbial rhodopsinSemantic proximity Read

Rationally tuning the reduction potential of a single cupredoxin beyond the natural range.Semantic proximity Read

Membrane association of the PTEN tumor suppressor: molecular details of the protein-membrane complex from SPR binding studies and neutron reflection.Semantic proximity Read

Palladium(II) and platinum(II) bind strongly to an engineered blue copper protein.Semantic proximity Read