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Integrative metagenomic and metabolomic analyses reveal severity-specific signatures of gut microbiota in chronic kidney disease

1 Jan 2020

Abstract excerpt

Chronic kidney disease (CKD) is a serious healthcare dilemma, associated with specific changes in gut microbiota and circulating metabolome. Yet, the functional capacity of CKD microbiome and its intricate relationship with the host metabolism at different stages of disease are less understood. METHODS: Here, shotgun sequencing of fecal samples and targeted metabolomics profiling of serum bile acids, short- and...

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PMID: 32373220
DOI: 10.7150/thno.41725

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