Article
Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Jan 2015
Rombouts Yoann, Ewing Ewoud, van de Stadt Lotte A, Selman Maurice H J, Trouw Leendert A, Deelder André M, Huizinga Tom W J, Wuhrer Manfred, van Schaardenburg Dirkjan, Toes René E M, Scherer Hans U
Abstract excerpt
OBJECTIVE: To determine whether anticitrullinated protein antibodies (ACPA) exhibit specific changes in Fc glycosylation prior to the onset of arthritis. METHODS: Serum samples of patients with ACPA-positive arthralgia (n=183) were collected at baseline and at various time points of follow-up. 105 patients developed arthritis after a median of 12 months (IQR 6-24) and were classified as having either rheumatoid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.