Article

Identifying Fundamental Gaps in Functional Metagenomics: A Step Towards Unlocking Microbiome Research Potential

2026-01-12

Abstract excerpt

Incomplete functional annotation systematically limits biological interpretation in microbiome studies and their translational potential. Poor annotation arises from multiple causes1 with incomplete gene-protein-reaction mapping being one tractable yet under-examined contributor. We address this gap by developing a comprehensive hierarchical framework that systematically integrates gene families in UniRef1 protein...

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Literature Corpus work: 0d8ad585-3b2c-55b6-ac29-9cf0b4c59539
DOI: 10.64898/2026.01.10.698778

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