Article

Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period

2019-12-02

Abstract excerpt

The optimal integration of molecularly targeted therapies with concurrent chemotherapy and radiation (CRT) to improve cures in genotype-defined cancers is unknown. Here, we develop a bio-mathematical framework to simulate patterns of local versus distant recurrences in a heterogeneous lung cancer population receiving combined targeted therapy and CRT. Our validated model predicts that targeted induction before CRT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d76ecda-0f54-5fef-a3af-aa2d5f44e510
DOI: 10.1101/861518

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction PeriodDOI 10.1101/861518Read

Personalized cancer treatment strategies incorporating irreversible and reversible drug resistance mechanismsSemantic proximity Read

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolutionSemantic proximity Read

Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies.Semantic proximity Read

Early ctDNA kinetics as a dynamic biomarker of cancer treatment responseSemantic proximity Read

Impact of Resistance on Therapeutic Design: A Moran Model of Cancer GrowthSemantic proximity Read

Clinically Validated Model Predicts the Effect of Intratumoral Heterogeneity on Overall Survival for Non-Small Cell Lung Cancer (NSCLC) PatientsSemantic proximity Read

A comparison of mutation and amplification-driven resistance mechanisms and their impacts on tumor recurrence.Semantic proximity Read

Optimizing Clinical Outcome and Toxicity in Lung Cancer Using a Genomic Marker of RadiosensitivitySemantic proximity Read

Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the EffortSemantic proximity Read

Local consolidative therapy after EGFR-TKI response in advanced EGFR-mutant NSCLC.Semantic proximity Read

A fractional-order model for optimizing combination therapy in heterogeneous lung cancer: integrating immunotherapy and targeted therapy to minimize side effects.Semantic proximity Read

Dynamic optimization of chemo–immunotherapy sequencing reveals phenotype-dependent regimens across tumor immune microenvironmentsSemantic proximity Read