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Charcot-Leyden Crystals drive pathology and inflammation in muco-obstructive lung disease

2025-11-27

Abstract excerpt

Mucus plugging leading to airway obstruction is a hallmark of chronic respiratory diseases, yet the biology of plugs and their contribution to airway inflammation remain poorly defined. Through guided retrieval and analysis of plugs from patients with allergic bronchopulmonary aspergillosis, we identify Charcot-Leyden crystals that are formed from eosinophil-derived Galectin-10 as ubiquitous and mechanistic compon...

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Identifiers and source

Literature Corpus work
0d09dace-e48e-5377-b8a9-ce1b3d6a6482
DOI
10.1101/2025.11.26.25341000
Open publication

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Charcot-Leyden Crystals drive pathology and inflammation in muco-obstructive lung diseaseDOI 10.1101/2025.11.26.25341000
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