Article

XAI-ecDNA: A Proof-of-Concept Framework for Explainable Multi-Modal Extrachromosomal DNA Detection Using Synthetic FISH and Genomics

2026-01-04

Abstract excerpt

Extrachromosomal DNA (ecDNA) is a key contributor to aggressive tumor evolution and drug resistance across multiple cancer types. Yet detection methods suffer from limited performance and lack interpretability. Moreover, paired fluorescence in situ hybridization (FISH) and genomic datasets necessary for developing multi-modal artificial intelligence tools remain unavailable in public repositories. We developed an...

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Literature Corpus work: 0cfdc1c7-7245-59f0-8e28-a7ab3f2bb335
DOI: 10.64898/2026.01.04.697565

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