Back to search

Article

Baseline Gut Microbiome Profiling in Therapy-Naive Patients with Locally Advanced Rectal Cancer Identifies Signatures of Response to Total Neoadjuvant Therapy

2026-06-03

Abstract excerpt

<h4>Background: </h4> /Objectives: Total neoadjuvant therapy (TNT) is standard for locally advanced rectal cancer, yet treatment response is biologically heterogeneous, underscoring the need for predictive biomarkers. This study aimed to characterize how baseline and on-treatment gut microbiome ecology relate to clinically relevant response dimensions, and to identify baseline-level markers that could be integrate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0cbd9bbf-ad8b-52b3-9db0-c38b59fc24f2
DOI
10.20944/preprints202606.0192.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Baseline Gut Microbiome Profiling in Therapy-Naive Patients with Locally Advanced Rectal Cancer Identifies Signatures of Response to Total Neoadjuvant TherapyDOI 10.20944/preprints202606.0192.v1
Exome and Tissue-Associated Microbiota as Predictive Markers of Response to Neoadjuvant Treatment in Locally Advanced Rectal CancerSemantic proximity
Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancerSemantic proximity
Tumour Microbiome-Based Subtypes of Colorectal Cancer Correlate with Clinical VariablesSemantic proximity
Gut Microbiome Composition Is Associated with a Pathologic Response After Preoperative Chemoradiation in Patients with Rectal CancerSemantic proximity
Young-onset Rectal CancerSemantic proximity
Interaction between intratumoral microbiota and tumor mediates the response of neoadjuvant therapy for rectal cancerSemantic proximity
Metagenomic analysis reveals effects of gut microbiome in response to neoadjuvant chemoradiotherapy in advanced rectal cancerSemantic proximity
Ecological and functional stratification of the stool microbiome predicts response to immune checkpoint inhibitors across cancer typesSemantic proximity
A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint InhibitorsSemantic proximity
Determination of biomarkers associated with neoadjuvant treatment response focusing on colibactin-producing Escherichia coli in patients with mid or low rectal cancer: a prospective clinical study protocol (MICARE)Semantic proximity
Identification and characterization of four bacteriome- and mycobiome-derived subtypes in tumour and adjacent mucosa tissue of colorectal cancer patientsSemantic proximity
Microbiome Dynamics During Chemoradiotherapy for Anal CancerSemantic proximity
Select a neighboring publication to make it the new centre.