Article

Ecological and functional stratification of the stool microbiome predicts response to immune checkpoint inhibitors across cancer types

2025-05-11

Abstract excerpt

Despite the recognized role of the gut microbiome in modulating immune checkpoint inhibitor (ICI) efficacy, the ecological principles governing this relationship remain elusive. Moving beyond cataloging specific bacteria, we investigated whether general ecosystem properties determine clinical outcome. Through genome-resolved metagenomic analysis, we constructed a comprehensive catalog from 951 stool metagenomes an...

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Literature Corpus work: f744e6b6-717a-5b11-87d9-56429a42f556
DOI: 10.1101/2025.05.07.652660

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