Article

Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3′UTR in Amyotrophic Lateral Sclerosis

2021-06-05

Abstract excerpt

The non-coding genome is substantially larger than the protein-coding genome but is largely unexplored by genetic association studies. Here, we performed region-based burden analysis of >25,000 variants in untranslated regions of 6,139 amyotrophic lateral sclerosis (ALS) whole-genomes and 70,403 non-ALS controls. We identified Interleukin-18 Receptor Accessory Protein (IL18RAP) 3′UTR variants significantly enriche...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c6f77c6-dfda-58ab-a331-b2db323c4e9d
DOI: 10.1101/2021.06.03.446863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3′UTR in Amyotrophic Lateral SclerosisDOI 10.1101/2021.06.03.446863Read

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALSSemantic proximity Read

The New York Genome Center ALS Consortium resource integrates postmortem tissue transcriptomics and whole genome sequencing to empower biological discoverySemantic proximity Read

The length of the expressed 3’ UTR is an intermediate molecular phenotype linking genetic variants to complex diseasesSemantic proximity Read

lncRNA 3222401L13Rik / ENSG00000272070 modulates microglial inflammatory programs in association with PU.1Semantic proximity Read

Integrative genetic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genesSemantic proximity Read

Wild-type C9orf72 expression is a genetic modifier of C9-ALS survivalSemantic proximity Read

Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genesSemantic proximity Read

Long non-coding and coding RNAs characterization in Peripheral Blood Mononuclear Cells and Spinal Cord from Amyotrophic Lateral Sclerosis patientsSemantic proximity Read

Genetic variants in mRNA untranslated regions.Semantic proximity Read

Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosisSemantic proximity Read

Integrative Multi-Omics Mendelian Randomization Highlights Causal Autophagy-Related Genes for Amyotrophic Lateral Sclerosis.Semantic proximity Read

Genome-wide functional screen of 3’UTR variants uncovers causal variants for human disease and evolutionSemantic proximity Read