Article

Molecular evolution and adaptation of SARS-CoV-2 omicron XBB sub-lineage Spike protein under African selection pressure

2023-08-17

Abstract excerpt

The SARS-CoV-2 Omicron variant of concern (VOC) has multiple mutations in the spike (S) protein, which mediates viral infection and immunity. We analysed a sub-lineage of Omicron, designated XBB, that showed structural and functional changes in the S protein in response to the African selection pressures. We used molecular modelling to compare the S protein structures of Omicron and XBB and found that XBB had a re...

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Literature Corpus work: 0c6cb1a6-f695-594f-9c6d-069b0e65e11a
DOI: 10.1101/2023.08.16.553557

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