Article

Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia

2022-02-08

Abstract excerpt

Acute myeloid leukemia (AML) is characterized by poor clinical outcomes due to high rates of relapse following standard-of-care induction chemotherapy. While many pathogenic drivers have been described in AML, our understanding of the molecular mechanisms mediating chemotherapy resistance remains poor. Therefore, we sought to identify resistance genes to induction therapy in AML and elucidated ALOX5 as a novel med...

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Literature Corpus work: 0c51ed8c-4685-521a-9be4-f5caf70e0802
DOI: 10.1101/2022.02.07.479440

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