Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CML With Mutant ASXL1 Showed Decreased Sensitivity to TKI Treatment via Upregulation of the ALOX5 ‐ BLTR Signaling Pathway

4 Feb 2025

Abstract excerpt

In this study, the mechanisms of tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) were investigated focusing additional sex combs-like 1 (ASXL1) gene mutations and their downstream effects. While TKIs have improved the prognosis of CML, some patients have shown resistant to therapy. Cases with mutations in epigenome-related genes such as ASXL1 are known to have a poor prognosis, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments
Share to Eosinophilic Disorders and Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39905783
DOI: 10.1111/cas.70007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CML With Mutant ASXL1 Showed Decreased Sensitivity to TKI Treatment via Upregulation of the ALOX5 ‐ BLTR Signaling PathwayPMID 39905783Read ↗

PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.Semantic proximity Read ↗

Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemiaSemantic proximity Read ↗

The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemiaSemantic proximity Read ↗

The ALOX5 inhibitor zileuton promotes sunitinib resistance in renal cell carcinoma by reprogramming lipid metabolismSemantic proximity Read ↗

The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancerSemantic proximity Read ↗

HHEX promotes myeloid transformation in cooperation with mutant ASXL1.Semantic proximity Read ↗

RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.Semantic proximity Read ↗

ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylationSemantic proximity Read ↗

[Relationship between Polymorphism in ALOX5, ALOX5AP and Susceptibility to Myeloid Leukemia].Semantic proximity Read ↗

A Receptor Tyrosine Kinase Inhibitor Sensitivity Prediction Model Identifies AXL Dependency in Leukemia.Semantic proximity Read ↗

LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 AxisSemantic proximity Read ↗

Frequency and prognostic influence of ASXL1 mutations and its potential association with BCR-ABL1 transcript type and smoke in chronic myeloid leukemia patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.