Article

A cocktail of antibodies to multiple tumor-specific neoantigens increases binding and inhibits tumor growth

2019-06-17

Abstract excerpt

<title>Abstract</title> <p>Background: Antibodies that target a single tumor antigen fail to cure stage IV cancer patients due to tumor heterogeneity resulting in variable expression of antigen. Tumor cells with insufficient binding of antibody will not undergo antibody induced cytotoxicity. We describe targeting multiple tumor-specific antigens that resulted in homogeneous dense binding to mouse melanoma cells a...

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Literature Corpus work: 0bf4faf8-9bcf-5d0e-a24e-34be837da0a1
DOI: 10.21203/rs.2.10383/v1

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