Article

Identifying commonalities between cell lines and tumors at the single cell level using Sobolev Alignment of deep generative models

2022-03-09

Abstract excerpt

Preclinical models are essential to cancer research, however, key biological differences with patient tumors result in reduced translatability to the clinic and high attrition rates in drug development. Variability among and between patients, preclinical models, and individual cells obscures commonalities which could otherwise be exploited therapeutically. To discover the shared biological processes between cell l...

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Literature Corpus work: 0bdc291e-81f2-5616-ab19-2216b241b029
DOI: 10.1101/2022.03.08.483431

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