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A Comparison of Pathogen Culture and Metagenomic Next-Generation Sequencing in Periprosthetic Joint Infections and Implications for Empirical Antibiotic Selection: An 9-Year Retrospective Study

2026-07-14

Abstract excerpt

<title>Abstract</title> <p> Background Periprosthetic joint infection (PJI) is a severe complication of total joint arthroplasty. Traditional microbial culture has notable limitations, frequently resulting in culture-negative cases. Although mNGS improves pathogen detection, comparative studies between the two methods are still insufficient. This study aimed to build a PJI pathogen database via culture and mNGS...

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Literature Corpus work: 0bd96899-ec57-534b-8855-1b7927d8e73e
DOI: 10.21203/rs.3.rs-9986871/v1

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