Genetic screens for genes controlling motor nerve-muscle development and interactions.

doi:10.1016/j.ydbio.2005.01.012

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Article

Genetic screens for genes controlling motor nerve-muscle development and interactions.

Developmental biology - 1 Apr 2005

Birely Joanne, Schneider Valerie A, Santana Evelyn, Dosch Roland, Wagner Daniel S, Mullins Mary C, Granato Michael

Abstract excerpt

Motor growth cones navigate long and complex trajectories to connect with their muscle targets. Experimental studies have shown that this guidance process critically depends on extrinsic cues. In the zebrafish embryo, a subset of mesodermal cells, the adaxial cells, delineates the prospective path of pioneering motor growth cones. Genetic ablation of adaxial cells causes profound pathfinding defects, suggesting...

Topics

Animals
Cell Differentiation
Cell Movement
Chimera
Embryo, Nonmammalian
Genetic Testing
Mesoderm
Morphogenesis
Motor Neurons
Muscle Development
Muscle, Skeletal
Mutation
Phenotype
Zebrafish

Source

Open in PubMed

Identifiers

PMID: 15766756
DOI: 10.1016/j.ydbio.2005.01.012

Provenance

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