Article

Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

2021-02-03

Abstract excerpt

The mitochondrial voltage-gated potassium channel, Kv1.3, has been emerged as an attractive oncologic target but its function in pancreas cancer (PDAC) is unknown. In this study we evaluated tissue expression of Kv1.3 in resected PDAC from 55 patients and tumor inhibition in orthotopic mouse models using the recently developed Kv1.3 inhibitors PCARBTP and PAPTP . Immunohistochemistry of 55 human PDAC specimens s...

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Literature Corpus work: 0ba397df-44e5-5330-9598-5ebea79a9ca0
DOI: 10.1101/2021.02.03.429505

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