Article
Molecular targeted therapies for pancreatic cancer.
American journal of surgery - 1 Sept 2008
Borja-Cacho Daniel, Jensen Eric Hans, Saluja Ashok Kumar, Buchsbaum Donald J, Vickers Selwyn Maurice
Abstract excerpt
BACKGROUND: Pancreatic cancer cells express different mutations that increase the aggressiveness and confer resistance to conventional chemotherapy and radiotherapy. Molecules that selectively bind and inhibit these mutations are effective in other solid tumors and are now emerging as a complementary therapy in pancreatic cancer. The objective of this review is to describe the effect of drugs that inhibit...
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