Article

Placental RNA sequencing implicates IGFBP1 in insulin sensitivity during pregnancy and in gestational diabetes

2023-10-27

Abstract excerpt

<title>Abstract</title> <p>Reduced insulin sensitivity (or greater insulin resistance) is a hallmark of normal physiology in late pregnancy and also underlies gestational diabetes mellitus (GDM) pathophysiology. We conducted transcriptomic profiling of 434 human placentas and identified a strong positive association between insulin-like growth factor binding protein 1 gene (<italic>IGFBP1</italic>) expression in...

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Literature Corpus work: 0b53198c-ba61-5d6f-9210-21b2d76c3bbf
DOI: 10.21203/rs.3.rs-3464151/v1

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