Article
Metabolomic and genetic associations with insulin resistance in pregnancy.
Diabetologia - 1 Sept 2020
Liu Yu, Kuang Alan, Talbot Octavious, Bain James R, Muehlbauer Michael J, Hayes M Geoffrey, Ilkayeva Olga R, Lowe Lynn P, Metzger Boyd E, Newgard Christopher B, Scholtens Denise M, Lowe William L
Abstract excerpt
AIMS/HYPOTHESIS: Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance. METHODS: Fasting and 1 h serum samples were collected from women in the Hyperglycemia and Adverse Pregnancy Outcome study who underwent an OGTT at ∼28 weeks' gestation. We obtained targeted and...
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