Article

AAV Ablates Neurogenesis in the Adult Murine Hippocampus

2020-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Recombinant adeno-associated virus (rAAV) has been widely used as a viral vector across mammalian biology and has been shown to be safe and effective in human gene therapy. We demonstrate that neural progenitor cells (NPCs) and immature dentate granule cells (DGCs) within the adult murine hippocampus are particularly sensitive to rAAV-induced cell death. Cell loss is dose dependent and nearly co...

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Literature Corpus work: 0b43f550-7745-5e30-a9fd-007d292ae3e1
DOI: 10.1101/2020.01.18.911362

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