Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.

doi:10.1200/JCO.2010.30.8338

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Article

Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2010

Sequist Lecia V, Gettinger Scott, Senzer Neil N, Martins Renato G, Jänne Pasi A, Lilenbaum Rogerio, Gray Jhanelle E, Iafrate A John, Katayama Ryohei, Hafeez Nafeeza, Sweeney Jennifer, Walker John R, Fritz Christian, Ross Robert W, Grayzel David, Engelman Jeffrey A, Borger Darrell R, Paez Guillermo, Natale Ronald

Abstract excerpt

PURPOSE: IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity has been validated in preclinical in vitro and in vivo models. We studied the activity of IPI-504 after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy in patients with advanced, molecularly defined non-small-cell lung cancer (NSCLC). PATIENTS AND...

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Identifiers

PMID: 20940188
DOI: 10.1200/JCO.2010.30.8338
PMCID: PMC4676802

Genes

EGFR
ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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