Article

Convergence of cytokines and hypoxia on colorectal cancer angiogenesis

2010-01-01

Abstract excerpt

Over-expression of Epidermal Growth Factor (EGF) and hypoxia are features of colorectal cancer (CRC). Such observations have helped develop novel therapies such as cetuximab, a recombinant monoclonal EGF receptor antibody antagonist. Recent studies uncovered a pro-angiogenic role for EGF but it is unclear whether this is mediated by Vascular Endothelial Growth Factor (VEGF) in CRC. Moreover, it is unknown whether...

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Literature Corpus work: 0b246b23-5499-5231-a337-9f1672e11f61
DOI: 10.25560/5701

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