Article

An integrated model for predicting KRAS dependency

2022-07-10

Abstract excerpt

<h4>Background</h4> The clinical approvals of KRAS G12C inhibitors has been a revolutionary advance in precision oncology, but response rates are often modest. To improve patient selection, we developed an integrated model to predict KRAS dependency. <h4>Methods and Findings</h4> By integrating molecular profiles of a large panel of cell lines from the DEMETER2 dataset, we built a binary classifier to predict a...

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Literature Corpus work: 0a445bde-8f92-581d-be20-200309371a72
DOI: 10.1101/2022.07.07.499238

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