Article
An integrated model for predicting KRAS dependency.
PLoS computational biology - 1 May 2023
Tsai Yihsuan S, Chareddy Yogitha S, Price Brandon A, Parker Joel S, Pecot Chad V
Abstract excerpt
The clinical approvals of KRAS G12C inhibitors have been a revolutionary advance in precision oncology, but response rates are often modest. To improve patient selection, we developed an integrated model to predict KRAS dependency. By integrating molecular profiles of a large panel of cell lines from the DEMETER2 dataset, we built a binary classifier to predict a tumor's KRAS dependency. Monte Carlo cross...
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