Article

Causal network perturbations for instance-specific analysis of single cell and disease samples

2019-05-16

Abstract excerpt

Complex diseases involve perturbation in multiple pathways and a major challenge in clinical genomics is characterizing pathway perturbations in individual samples. This can lead to patient-specific identification of the underlying mechanism of disease thereby improving diagnosis and personalizing treatment. Existing methods rely on external databases to quantify pathway activity scores. This ignores the data depe...

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Literature Corpus work: 0920fffb-974a-538f-b726-ef5220bcd80b
DOI: 10.1101/637710

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