Article

Normative modeling for quantitative brain MRI phenotyping and biomarker discovery for pediatric leukodystrophies

2026-05-25

Abstract excerpt

<h4>Importance</h4> Leukodystrophies are a heterogeneous group of genetic disorders affecting the white matter of the brain, often presenting with overlapping clinical features but differing in neuroanatomical involvement. There is a critical need for quantitative tools to characterize disease burden and support diagnosis, severity stratification, and clinical trial readiness. <h4>Objective</h4> To characterize...

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Literature Corpus work: 090e047e-6bd0-5a3a-9447-2fabf1394c15
DOI: 10.64898/2026.05.22.26353512

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