Article

Automated Deep Learning–Based Demyelination Load Segmentation in Metachromatic Leukodystrophy

2025-11-10

Abstract excerpt

<title>Abstract</title> <p> Purpose Metachromatic leukodystrophy (MLD) is a rare lysosomal storage disorder characterized by progressive white matter demyelination. Quantification of demyelinated white matter on MRI—typically expressed as the <italic>demyelination load</italic> —serves as a key imaging biomarker of disease burden, enabling objective monitoring beyond visual rating scales. However, current semi...

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Literature Corpus work: 871c72ef-5b00-58ab-ab2a-55d2580a1c8b
DOI: 10.21203/rs.3.rs-7924598/v1

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