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Alveolar macrophages are early targets of mumps virus

19 Dec 2024

Abstract excerpt

Formerly a common childhood pathogen, mumps virus (MuV) remains active worldwide, despite relatively high vaccine coverage. MuV is thought to infect the upper respiratory tract before disseminating to other organs; however, the early cellular targets of MuV in vivo are unknown. To address this, we generated a green fluorescent protein (GFP)-tagged vaccine strain (JL5) of MuV to infect leukocytic cell lines and...

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PMID: 39700136
DOI: 10.1073/pnas.2410954121

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